A new class of drugs that mimic the hormone GLP-1 are helping people lose weight in part by changing how they think about food. Scientific American associate health editor Lauren J. Young covers newfound connections between the gut and brain. Obesity is now classified as a disease, but not everyone with obesity has symptoms of poor health, such as high blood pressure or insulin resistance. New research ex­­plores the unusual phenomenon of people who are heavy and healthy, and author Christie Aschwanden breaks down changing conceptions of weight and fat. Our Graphic Science column spells out what vitamins and minerals we need and how they act in the body.