But even though Moore was such a visible celebrity of my teenage and early adult years, I never felt I knew much about her until reading her revealing 2019 memoir, “Inside Out,” which opens at the lowest point in her life, with the end of her marriage to Ashton Kutcher and her relapse into alcoholism. Moore’s struggles started early as the child of a mentally ill, alcoholic mother. But much of the book is about the extreme lengths she went to during her prime Hollywood days to control her body through disordered eating and exercise. Now in her 60s and a grandmother, Moore tells me she has finally grown comfortable in her own skin and, with “The Substance” and this stage of her career, is hoping to upend expectations about what it means to be an aging woman in an industry that both embraced and judged her harshly. (And a note: I asked Moore how her former husband Bruce Willis, who’s living with frontotemporal dementia, is doing, and she said he’s stable and OK, all things considered.)